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Amplia's Fibrosis Program

Fibrosis is the formation of excessive fibrous connective tissues that can result from chronic inflammation, chronic injury or disease. This excessive fibrous tissue can impair the normal functioning of various organs in the body, such as the lungs, liver, heart and kidneys, resulting in major health issues.​

Focal Adhesion Kinase (FAK) plays an important role in fibrotic disease. Amplia’s FAK inhibitors have been shown to block fibrosis in established animal models of both lung fibrosis and liver fibrosis (NASH).​

Amplia's FAK Inhibitors in an animal model of lung fibrosis

Amplia's FAK Inhibitors in an animal model of liver fibrosis

Amplia is planning to initiate a Phase 2 clinical trial of AMP945 in patients with Idiopathic Pulmonary Fibrosis (IPF or lung fibrosis) in 2022 and is currently evaluating both AMP945 and AMP886 in animal models of various fibrotic disease.​