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Background - FAK

Focal Adhesion Kinase (FAK) is an increasingly important target in the field of cancer immunology. FAK also plays a significant role in a number of chronic diseases, such as idiopathic pulmonary fibrosis (IPF).

Focal Adhesion Kinase -101

  • Fibrosis is the formation of excess connective tissue which can adversely affect normal organ or tissue architecture and function
  • Fibrosis can help shield certain tumours from the immune system rendering many cancer treatments ineffective
  • FAK is an important cell adhesion modulator and plays a central role in the formation of fibrosis, both in cancer and fibrotic diseases
  • Inhibiting FAK has the potential to sensitize treatment-resistant cancers to existing chemotherapeutics and provide a much-needed breakthrough in the treatment of cancers that demonstrate limited response to immuno-oncology therapies